Icosavax begins early-stage research of bivalent RSV/hMPV vaccine IVX-A12

Icosavax (NASDAQ:ICVX) mentioned it started a part 1 trial of its mixture bivalent vaccine candidate towards respiratory syncytial virus (RSV) and human metapneumovirus (hMPV), IVX-A12 in older adults.

HMPV could cause higher and decrease respiratory illness in folks of all ages, particularly amongst younger kids, older adults, and folks with weakened immune methods, in line with the U.S. CDC.

IVX-A12 consists of IVX-121, RSV prefusion F protein VLP vaccine candidate, and IVX-241, hMPV prefusion F protein VLP vaccine candidate, the corporate mentioned in an Oct. 4 press launch.

In June, Icosavax had reported information from a part 1 trial of the RSV vaccine IVX-121.

Icosavax mentioned that with the trial initiation, IVX-A12 turns into the primary mixture bivalent vaccine candidate towards each RSV and hMPV to enter scientific stage, and the primary candidate from the corporate’s VLP platform to obtain IND (investigational new drug) authorization within the U.S.

“Not solely is IVX-A12 Icosavax’s first mixture bivalent VLP vaccine candidate, it’s also probably the most superior vaccine candidate towards each RSV and hMPV in older adults, and the one scientific stage VLP on this area,” mentioned Icosavax CEO Adam Simpson.

The corporate expects part 1 topline interim leads to mid-2023 and part 2 begin deliberate to observe in H2 2023.