Pfizer, BioNTech begin trial of next-gen COVID-19 vaccine for broader safety

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Pfizer (NYSE:PFE) and BioNTech (NASDAQ:BNTX) mentioned they began a part 1 trial of a subsequent technology COVID-19 vaccine which goals to reinforce SARS-CoV-2 T cell responses and doubtlessly broaden safety in opposition to COVID-19.

The candidate, BNT162b4, consists of a T cell antigen mRNA encoding for novel coronavirus non-spike proteins that are extremely conserved throughout a broad vary of SARS-CoV-2 variants and will likely be evaluated together with the businesses’ Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine.

The businesses added that these non-spike proteins have been chosen based mostly on BioNTech’s proprietary goal prioritization platform and have been designed right into a vaccine candidate with the aim of broadening T cell immunity and doubtlessly extending sturdiness of safety in opposition to COVID.

BNT162b4 will likely be evaluated in a U.S.-based trial enrolling ~180 wholesome individuals aged between 18 years and 55 years, who’ve acquired at the least three doses of an mRNA-based COVID-19 vaccine.

The trial research will discover completely different dose ranges of BNT162b4 given together with a 30-µg dose of the businesses’ Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine and will likely be in comparison with the administration of a 30-µg dose of the Omicron BA.4/BA.5-adapted bivalent COVID vaccine as a booster.

This research is a part of the businesses’ efforts to develop a number of vaccines with the goal of delivering a possible pan COVID-19 vaccine.

BNTX +0.60% to $165.89 premarket Nov. 17

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